Good morning. In today’s edition:

• ✈️ At a premium
• 💊 “Living pharmacy”
• 🖼️ 3-minute art heist

…and much more.

Ready, Set, Go: Today’s news should be a ~4.07-minute read (1,083 words).

Did someone forward you this email? Subscribe here for free.

"If you're not making mistakes, then you're not doing anything. I'm positive that a doer makes mistakes."

–John Wooden (1910-2010)

A growing number of airlines are embracing a simple truth about flying: legroom sells.

Across the industry, airlines are reworking their planes to fit more premium seats, and cutting back on standard economy in the process. The goal is simple: make more money per flight by catering to travelers willing to pay up for comfort.

By the numbers: Premium economy seats can sell for double the price of a regular economy ticket while taking up only slightly more space, per the Global Tourism Forum. And that math is hard for airlines to ignore.

Since January 2020, the number of business and first-class seats on domestic flights has risen by 27%, per Visual Approach Analytics. Meanwhile, economy seats have grown just 10%.

The trend exists across the industry

Delta says households earning over $100,000 now make up ~75% of all airline leisure spending. In response, the company is doubling down on that group by adding more first-class seats and expanding its Delta One suites, per CEO Ed Bastian.

• United is taking a similar approach with its new “elevated” Dreamliner, where just 40% of seats are standard economy (down from 58% currently). United also recently announced a new “Relax Row” allowing passengers to pay extra to transform a row of economy seats into a makeshift couch.
• American Airlines has also boosted its premium seat count by more than a third over the past decade.

Bottom line: Analysts say adding more premium economy options gives airlines a revenue system that can adapt to different consumer behaviors. Basic economy passengers can upgrade when spending is strong, while business-class travelers can trade down to premium economy when purse strings tighten.

In crypto everyone sounds right until the next move hits. Being late or early can be the same as being wrong. Most people don't lose from missing information, they lose from not knowing what to do in time.

The DeFi Report newsletter shows how they're actually positioned and when they change it. No second guessing, no noise.

They moved to cash near October's top and called Bitcoin's drop to 65k before it happened.

Millions of people go to the pharmacy to pick up their meds every day. But what if the pharmacy came to you instead—and even took your pills for you?

That’s the idea of a new implantable “living pharmacy” developed by a scientific team co-led by Northwestern, Rice, and Carnegie Mellon.

How it works

The tiny device—roughly the size of a folded stick of gum—contains engineered cells that continuously produce medicines inside the body.

• In a new study, researchers programmed those cells to simultaneously produce three different treatments: an anti-HIV antibody, a GLP-1-like peptide for type 2 diabetes and a hormone regulating appetite and metabolism (leptin).
• When implanted under the skin of an animal model, the “living pharmacy” kept the drug-producing cells alive and successfully delivered all three treatments at once.

Called HOBIT (Hybrid Oxygenation Bioelectronics system for Implanted Therapy), the tiny device shields the engineered cells from the body’s immune system while also keeping them alive with oxygen and nutrients, allowing the cells to produce biologic drugs for several weeks.

The potential impact: While more work is needed, scientists say their “living pharmacy” design could eventually bypass the need for patients to carry, inject, or remember to take medications.

BUSINESS & MARKETS

• 💰 Dept. of Labor proposes new rule to allow 401(k) plans to more easily include alternative assets like crypto, real estate, and private market assets.
• 🍽️ Sysco, the biggest US food distributor to restaurants, hospitals, and schools, agrees to buy Restaurant Depot for ~$29 billion, including debt.
• ✈️ Air Canada CEO Michael Rousseau to step down amid backlash over his handling of the March 22 crash at NYC’s LaGuardia Airport that killed two Air Canada pilots. | JetBlue raises checked bag fees by $9 during peak hours ($4 non-peak) as jet fuel prices soar amid the Iran war.

SPORTS, MEDIA & ENTERTAINMENT

• 🪄 First trailer for HBO’s upcoming Harry Potter series surpasses 277 million views across platforms; it’s the most-watched trailer in HBO history.
• 🎤 BLACKPINK's Lisa to be the first K-pop star with a Las Vegas residency, which begins in November 2026.
• 🏒 Las Vegas Golden Knights fire head coach Bruce Cassidy and name John Tortorella as his replacement.

Building a fully working app is now one conversation away.

Floot lets you create real, working products just by describing what you want. Adjust the layout visually, launch instantly, and keep everything running without managing the backend.

From jumpstarting side projects to internal business tools that replace expensive software. If you can describe it, Floot can build it.

SCIENCE, SPACE & EMERGING TECH

• 🗿 “Israel’s Stonehenge,” or massive stone circles in the Golan Heights long thought to be a singular anomaly, is actually the centerpiece of a much larger, previously hidden phenomenon, new research shows.
• 🧘 Regular, high-intensity yoga is better at improving sleep compared to a range of other exercises, including walking, resistance training, combination exercise, aerobic exercise, and traditional Chinese exercises like tai chi.
• 🧑‍🚀 Astronaut who prompted NASA's first-ever medical evacuation from the ISS says doctors still don't know why he suddenly fell sick; four-time space flier Mike Fincke says he suddenly couldn’t speak, in episode that lasted ~20 mins and hasn’t returned.

US, WORLD & POLITICS

• 💥 Iran war: President Trump says “great progress has been made” towards a peace deal with Iran; however, Trump also says if a deal isn’t reached “shortly” and the Strait of Hormuz is not “immediately” reopened, the US would attack key Iranian energy infrastructure; Israel’s largest oil refinery is reportedly hit by Iranian missile, as Israel launches a series of new strikes on Iran.
• 🇨🇺 President Trump says he has “no problem” allowing Russian oil tanker to reach Cuba; press secretary Karoline Leavitt later says tanker was allowed through for “humanitarian reasons,” and doesn’t signal end of ongoing US fuel blockade on Cuba.
• 🖼️ Thieves broke into a private art museum in the Italian city of Parma earlier this month; in three minutes, the group made off with works by Renoir, Cézanne, and Matisse worth a collective ~$9 million.

👆 Hummingbird Nest Ranch, a California equestrian estate used as a filming site for shows like The Bachelorette, has been put on the market for an asking price of $78 million. The 124-acre property includes a 17,000-sq-ft villa along with numerous guesthouses and apartments.

🤔 Did you know? Every working dog in the military is a non-commissioned officer by tradition, per the US Army. Some say the custom originated to prevent handlers from mistreating their dogs by ensuring canines are always one rank higher than their handlers.

📰 Worth a read: How working in America became so joyless

🖱️ What we’re clicking:

• Unabomber: the serial killer unmasked by his own writing
• The top fast-food spot for marriage proposals
• Is too much smartphone use giving you "tech neck"?

The pair you forget you’re wearing… Saalt’s Seamless Leakproof Briefs combine barely-there seamless fabric with their patented thinnest, driest leakproof technology for comfort and confidence you don’t think twice about. BOGO 50% off with code SEAMLESS50.

Yesterday we covered how the ongoing war in Iran has now entered its second month, with the US military reportedly preparing for a potential ground invasion in Iran, as peace negotiations remain ongoing but slow.

❓ Our question to you (long-form): What are your thoughts on the ongoing conflict in the Middle East?

• “I believe it's going to lead to more chaos in the future. They will never fully wipe out radical groups. And radical groups tend to have long memories. They may take years to strike back but I have no doubt that they will.”
• “It is unfortunate that there are criminals and terrorists in the world, but there are. Eventually you must stand up for yourself. Iran forces executed 30,000 Iranians a few weeks ago. It's challenging to have perspective and compare or justify what it taking place today.”
• “The US made significant strategic errors in attacking Iran - most notably carrying out the strikes during the holy month of Ramadan. Although this has not been widely covered in the media, the timing likely intensified the conflict and helped frame it as a religious struggle, drawing broader sympathy from Muslim communities and will make it harder to de-escalate.”

Click here to read more of the most thoughtful longform responses.

+Note on sample size: We received 54 longform responses.

🙃 The Thatcher Effect: There’s a strange optical illusion when it comes to inverted human faces.

🌐 Play: Six Degrees of Wikipedia is a game where you try to connect two seemingly unrelated articles in six clicks or fewer.

📵 Tired of wasting time on apps? Dopa-Mean adds a mandatory 30-second pause to social media apps, giving your brain a moment to decide whether you really want to start scrolling.

🏢 Want to know how media companies actually get built? Letters by Evernomic features interviews with industry experts and stories on media, technology, and company building. Join thousands of founders who read us every week.*

*A message from our partners

❓ Trivia: Which metal, in its purest form, has the highest melting point?

🎓 True or false?...The collarbone is the most commonly broken human bone

🤔 Riddle me this: A person goes bankrupt for pushing their car into a hotel. Why?

❤️ WWII veteran Dale Steele recently proved that generosity has no age limit, becoming the oldest organ donor in US history following his death at 100 years old.

❓ Trivia: Tungsten

🎓 T/F: True

🤔 Riddle: They were playing Monopoly

Advertise with us: Want to reach other smart and inquisitive readers like you? Become a DONUT partner here.